Focus on Molecules: Collagens V and XI
نویسندگان
چکیده
منابع مشابه
Focus on molecules: heparanase.
Heparanase (NP_001092010) is a heparin-binding endo-bD-glucuronidase expressed by normal lacrimal gland (GEO Profiles: GDS1361), corneal epithelia (Berk et al., 2004), retinal pigment epithelium/choroid, lens (NEIBank) and some non-ocular tissues. Heparanase is over-expressed in essentially all human tumors examined. Western blotting suggests that heparanase is a constituent of normal tears (Ma...
متن کاملFocus on molecules: rootletin.
Rootletin (accession number NP_742120) is a large coiled coil protein initially identified as a structural component of the ciliary rootlet (Yang et al., 2002). Its formal designation (ciliary rootlet coiled-coil, rootletin), as listed in most databases, reflects these two known aspects of the protein. The murine rootletin comprises 2009 amino acid residues and has a calculated molecular weight...
متن کاملFocus on molecules: sulfotyrosine.
Besides being a precursor for neurotransmitters, hormones and melanin, tyrosine is a non-essential amino acid that is utilized by the eukaryotic cell to synthesize proteins. Once incorporated into proteins, tyrosine can be post-translationally modified by virtue of its side chain hydroxyl group by nitration, phosphorylation and sulfation. While nitrotyrosine is synthesized through a nonenzymati...
متن کاملFocus on molecules: lacritin.
Lacritin is a 12.3 kDa secreted tear protein in human (accession Q9GZZ8 [Genpept; UniProt; Sanghi et al., 2001]) and non-human primates. It consists of 119 aa after removal of the signal peptide (SP; Fig. 1) and has a predicted isoelectric point (pI ) of 5. Predicted values for secreted lacritin in non-human primates include the following: 12.2 kDa and pI of 5 (Chlorocebus aethiops), 12.3 kDa a...
متن کاملRegulation of collagen fibril nucleation and initial fibril assembly involves coordinate interactions with collagens V and XI in developing tendon.
Collagens V and XI comprise a single regulatory type of fibril-forming collagen with multiple isoforms. Both co-assemble with collagen I or II to form heterotypic fibrils and have been implicated in regulation of fibril assembly. The objective of this study was to determine the roles of collagens V and XI in the regulation of tendon fibrillogenesis. Flexor digitorum longus tendons from a haplo-...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Experimental Eye Research
سال: 2012
ISSN: 0014-4835
DOI: 10.1016/j.exer.2010.08.003